"We all know this. Now is not the time to simply list and lament challenges. Now is the time to act," said Guterres.
The world must go into emergency mode in the COVID-19 battle, he said.
Omicron is yet another warning. The next variant may be worse. Stopping the spread anywhere must be at the top of the agenda everywhere, he said.
Actions must be grounded in science and common sense. The science is clear: vaccines work, vaccines save lives. But the distribution of vaccines is scandalously unequal, he said. "Instead of the virus spreading like wildfire, we need vaccines to spread like wildfire. We need all countries and all manufacturers to prioritize vaccine supply to COVAX and create the conditions for the local production of tests, vaccines and treatments in so many countries able to do it around the world."
The World Health Organization in October 2021 unveiled a strategy to vaccinate 40 percent of people in all countries by the end of 2021, and 70 percent by the middle of 2022, he noted. "We are nowhere near these targets. Vaccination rates in high-income countries are seven times higher than in the countries of Africa. At this rate, Africa will not meet the 70 percent threshold until August 2024."
There is also a need to fight the plague of vaccine misinformation. More needs to be done to ready the world for the next outbreak, including by strengthening the authority of the World Health Organization, he said.
The world must go into emergency mode to reform global finance, said Guterres.
"Let's tell it like it is: the global financial system is morally bankrupt. It favors the rich and punishes the poor," he said. One of the main functions of the global financial system is to ensure stability by supporting economies through financial shocks. Yet faced with precisely such a shock -- a global pandemic -- it has failed the Global South.
Lopsided investment is leading to a lopsided recovery. Low-income countries are experiencing their slowest growth in a generation. Many middle-income countries are ineligible for debt relief despite surging poverty and the growing impact of the climate crisis. Women and girls, who represent the majority of poor in most regions, are paying a high price in lost health care, education and jobs, he noted.
"Unless we take action now, record inflation, soaring energy prices and extortionate interest rates could lead to frequent debt defaults in 2022, with dire consequences for the poorest and most vulnerable," he warned.
The divergence between developed and developing countries is becoming systemic -- a recipe for instability, crisis and forced migration. These imbalances are not a bug, but a feature of the global financial system. They are inbuilt and structural. They are the product of a system that routinely ascribes poor credit ratings to developing economies, starving them of private finance, he said.
"Since the start of the pandemic, I have called for reform of the global financial system to support the needs of developing countries through an inclusive and transparent process. To build a strong recovery, governments need the resources to invest in people and resilience, through national budgets and plans anchored in the Sustainable Development Goals. All countries must be able to invest in strong health and education systems, job creation, universal social protection, gender equality and the care economy, and a just transition to renewable energy," he said.
"This requires a serious review of global financial governance mechanisms, which are dominated by the richest economies in the world." he added.
Reforming the global financial architecture requires an operational debt relief and restructuring framework. It means redirecting the Special Drawing Rights of the International Monetary Fund to countries that need help now. It requires a fairer global tax system, in which some of the trillions amassed by billionaires during the pandemic are shared more broadly. It means addressing illicit financial flows. It requires boosting the resources of multilateral development banks so they can better support developing economies, both directly and by leveraging private investment, he said.